Barkley will undergo surgery to repair his knee. The procedure typically comes with 10-12 months of recovery, meaning he should be sidelined for the remainder of the year.
The 23-year-old was off to a slow start in 2020, compiling only 34 yards on 19 carries. He eclipsed 1,000 rushing yards in each of his first two campaigns.
New York is 0-2 heading into a Week 3 encounter with the San Francisco 49ers.